In vivo detection of iron and neuromelanin by transcranial sonography: A new approach for early detection of substantia nigra damage
Identifieur interne : 003887 ( Main/Exploration ); précédent : 003886; suivant : 003888In vivo detection of iron and neuromelanin by transcranial sonography: A new approach for early detection of substantia nigra damage
Auteurs : Luigi Zecca [Italie] ; Daniela Berg [Allemagne] ; Thomas Arzberger [Allemagne] ; Petra Ruprecht [Allemagne] ; Wolf D. Rausch [Autriche] ; Massimo Musicco [Italie] ; Davide Tampellini [Italie] ; Peter Riederer [Allemagne] ; Manfred Gerlach [Allemagne] ; Georg Becker [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-10.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Fer.
English descriptors
- KwdEn :
- Apoferritins, Early Diagnosis, Female, Ferritin, Ferritins (metabolism), Fluorodeoxyglucose F18 (diagnostic use), Humans, Iron, Iron (metabolism), Locus niger, Male, Medical screening, Melanins (metabolism), Middle Aged, Nerve Degeneration (pathology), Nervous system diseases, Parkinson Disease (metabolism), Parkinson Disease (pathology), Parkinson Disease (ultrasonography), Parkinson disease, Parkinson's disease, Radiopharmaceuticals (diagnostic use), Sonography, Substantia Nigra (metabolism), Substantia Nigra (pathology), Substantia Nigra (ultrasonography), Surgical approach, Ultrasonography, Doppler, Transcranial (methods), Ultrasound, ferritins, neuromelanin, substantia nigra echogenicity, transcranial ultrasound.
- MESH :
- chemical , diagnostic use : Fluorodeoxyglucose F18, Radiopharmaceuticals.
- chemical , metabolism : Ferritins, Iron, Melanins.
- chemical : Apoferritins.
- metabolism : Parkinson Disease, Substantia Nigra.
- methods : Ultrasonography, Doppler, Transcranial.
- pathology : Nerve Degeneration, Parkinson Disease, Substantia Nigra.
- ultrasonography : Parkinson Disease, Substantia Nigra.
- Early Diagnosis, Female, Humans, Male, Middle Aged.
Abstract
Early diagnosis of Parkinson's disease (PD) in nonsymptomatic patients is a key issue. An increased echogenicity of the substantia nigra (SN) was found previously in Parkinsonian patients and in a low percentage of healthy adults. These nonsymptomatic subjects also showed a reduced 18F‐dopa uptake in striatum, suggesting a preclinical injury of the nigrostriatal system that could later proceed into PD. To investigate the ability of ultrasonography to detect markers of SN degeneration, such as iron deposition and neuromelanin depletion, we scanned postmortem brains from normal subjects at different ages by ultrasound and measured the echogenic area of the SN. The SN was then dissected and used for histological examinations and determination of iron, ferritin, and neuromelanin content. A significant positive correlation was found between the echogenic area of the SN and the concentration of iron, H‐ and L‐ferritins. Multivariate analysis carried out considering the iron content showed a significant negative correlation between echogenicity and neuromelanin content of the SN. In PD, a typical loss of neuromelanin and increase of iron is observed in this brain area. The finding of a positive correlation between iron and ferritin levels and a negative correlation of neuromelanin content with the area of echogenicity at the SN could therefore provide an interesting basis for diagnosis and therapeutic follow‐up studies in PD. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20550
Affiliations:
- Allemagne, Autriche, Italie
- Bade-Wurtemberg, Bavière, District de Basse-Franconie, District de Tübingen, Vienne (Autriche)
- Tübingen, Vienne (Autriche), Wurtzbourg
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Le document en format XML
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Rausch</name><affiliation wicri:level="3"><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Medical Chemistry, Veterinary University, Wien</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Musicco, Massimo" sort="Musicco, Massimo" uniqKey="Musicco M" first="Massimo" last="Musicco">Massimo Musicco</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biomedical Technologies‐CNR, Segrate (Milano)</wicri:regionArea><wicri:noRegion>Segrate (Milano)</wicri:noRegion></affiliation></author><author><name sortKey="Tampellini, Davide" sort="Tampellini, Davide" uniqKey="Tampellini D" first="Davide" last="Tampellini">Davide Tampellini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biomedical Technologies‐CNR, Segrate (Milano)</wicri:regionArea><wicri:noRegion>Segrate (Milano)</wicri:noRegion></affiliation></author><author><name sortKey="Riederer, Peter" sort="Riederer, Peter" uniqKey="Riederer P" first="Peter" last="Riederer">Peter Riederer</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinical Neurochemistry, Clinic and Policlinic for Psychiatry and Psychotherapy and NPF Center of Excellence Laboratories, University of Würzburg, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Gerlach, Manfred" sort="Gerlach, Manfred" uniqKey="Gerlach M" first="Manfred" last="Gerlach">Manfred Gerlach</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry and Psychotherapy, University of Würzburg, Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Becker, Georg" sort="Becker, Georg" uniqKey="Becker G" first="Georg" last="Becker">Georg Becker</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Saarland University, Homburg</wicri:regionArea><wicri:noRegion>Homburg</wicri:noRegion><wicri:noRegion>Homburg</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-10">2005-10</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1278">1278</biblScope><biblScope unit="page" to="1285">1285</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">20FB1218F8F8F614171B59B121C9F4B243D635AF</idno><idno type="DOI">10.1002/mds.20550</idno><idno type="ArticleID">MDS20550</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apoferritins</term><term>Early Diagnosis</term><term>Female</term><term>Ferritin</term><term>Ferritins (metabolism)</term><term>Fluorodeoxyglucose F18 (diagnostic use)</term><term>Humans</term><term>Iron</term><term>Iron (metabolism)</term><term>Locus niger</term><term>Male</term><term>Medical screening</term><term>Melanins (metabolism)</term><term>Middle Aged</term><term>Nerve Degeneration (pathology)</term><term>Nervous system diseases</term><term>Parkinson Disease (metabolism)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (ultrasonography)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Radiopharmaceuticals (diagnostic use)</term><term>Sonography</term><term>Substantia Nigra (metabolism)</term><term>Substantia Nigra (pathology)</term><term>Substantia Nigra (ultrasonography)</term><term>Surgical approach</term><term>Ultrasonography, Doppler, Transcranial (methods)</term><term>Ultrasound</term><term>ferritins</term><term>neuromelanin</term><term>substantia nigra echogenicity</term><term>transcranial ultrasound</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Fluorodeoxyglucose F18</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Ferritins</term><term>Iron</term><term>Melanins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Apoferritins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Ultrasonography, Doppler, Transcranial</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Nerve Degeneration</term><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Parkinson Disease</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Early Diagnosis</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dépistage</term><term>Exploration ultrason</term><term>Fer</term><term>Ferritine</term><term>Locus niger</term><term>Parkinson maladie</term><term>Système nerveux pathologie</term><term>Ultrason</term><term>Voie abord</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Fer</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Early diagnosis of Parkinson's disease (PD) in nonsymptomatic patients is a key issue. An increased echogenicity of the substantia nigra (SN) was found previously in Parkinsonian patients and in a low percentage of healthy adults. These nonsymptomatic subjects also showed a reduced 18F‐dopa uptake in striatum, suggesting a preclinical injury of the nigrostriatal system that could later proceed into PD. To investigate the ability of ultrasonography to detect markers of SN degeneration, such as iron deposition and neuromelanin depletion, we scanned postmortem brains from normal subjects at different ages by ultrasound and measured the echogenic area of the SN. The SN was then dissected and used for histological examinations and determination of iron, ferritin, and neuromelanin content. A significant positive correlation was found between the echogenic area of the SN and the concentration of iron, H‐ and L‐ferritins. Multivariate analysis carried out considering the iron content showed a significant negative correlation between echogenicity and neuromelanin content of the SN. In PD, a typical loss of neuromelanin and increase of iron is observed in this brain area. The finding of a positive correlation between iron and ferritin levels and a negative correlation of neuromelanin content with the area of echogenicity at the SN could therefore provide an interesting basis for diagnosis and therapeutic follow‐up studies in PD. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>Italie</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>District de Basse-Franconie</li><li>District de Tübingen</li><li>Vienne (Autriche)</li></region><settlement><li>Tübingen</li><li>Vienne (Autriche)</li><li>Wurtzbourg</li></settlement></list><tree><country name="Italie"><noRegion><name sortKey="Zecca, Luigi" sort="Zecca, Luigi" uniqKey="Zecca L" first="Luigi" last="Zecca">Luigi Zecca</name></noRegion><name sortKey="Musicco, Massimo" sort="Musicco, Massimo" uniqKey="Musicco M" first="Massimo" last="Musicco">Massimo Musicco</name><name sortKey="Tampellini, Davide" sort="Tampellini, Davide" uniqKey="Tampellini D" first="Davide" last="Tampellini">Davide Tampellini</name></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Berg, Daniela" sort="Berg, Daniela" uniqKey="Berg D" first="Daniela" last="Berg">Daniela Berg</name></region><name sortKey="Arzberger, Thomas" sort="Arzberger, Thomas" uniqKey="Arzberger T" first="Thomas" last="Arzberger">Thomas Arzberger</name><name sortKey="Becker, Georg" sort="Becker, Georg" uniqKey="Becker G" first="Georg" last="Becker">Georg Becker</name><name sortKey="Gerlach, Manfred" sort="Gerlach, Manfred" uniqKey="Gerlach M" first="Manfred" last="Gerlach">Manfred Gerlach</name><name sortKey="Riederer, Peter" sort="Riederer, Peter" uniqKey="Riederer P" first="Peter" last="Riederer">Peter Riederer</name><name sortKey="Ruprecht, Petra" sort="Ruprecht, Petra" uniqKey="Ruprecht P" first="Petra" last="Ruprecht">Petra Ruprecht</name><name sortKey="Ruprecht, Petra" sort="Ruprecht, Petra" uniqKey="Ruprecht P" first="Petra" last="Ruprecht">Petra Ruprecht</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Rausch, Wolf D" sort="Rausch, Wolf D" uniqKey="Rausch W" first="Wolf D." last="Rausch">Wolf D. Rausch</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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